From Research to Reality: How Young Plasma Exchange® Is Reversing Biological Age
A New Milestone in Longevity Science
In May 2025, researchers at the Buck Institute for Research on Aging published a groundbreaking clinical trial that marks a major step forward in reversing biological age.
The study, featured in Aging Cell, revealed that Therapeutic Plasma Exchange (TPE)—particularly when combined with Intravenous Immunoglobulin (IVIG)—can make the body biologically younger by an average of 2.6 years.
Using advanced multi-omics testing, scientists measured how plasma exchange affected DNA methylation, proteomics, metabolomics, and immune function—the molecular markers that define how our body ages.
In simple terms: we now have evidence that reversing biological age is scientifically possible through targeted plasma-based therapies that rejuvenate the body at the cellular level.
What Is Therapeutic Plasma Exchange (TPE)?
Think of Therapeutic Plasma Exchange as an “oil change for your bloodstream.”
During TPE, the plasma—the fluid portion of your blood that carries proteins, inflammatory molecules, and metabolic by-products—is gently removed and replaced with a clean, albumin-based solution.
This process clears out age-related, pro-inflammatory molecules and cellular debris, allowing the body’s systems to “reset.” The result is improved cell-to-cell communication, enhanced metabolic efficiency, and better overall tissue function.
TPE has been used safely in hospitals for decades to address autoimmune and neurological conditions. Now, it’s emerging as a powerful modality for reversing biological age and supporting systemic rejuvenation.
The Buck Institute Study: 2.6 Years of Biological Age Reversal
In the 2025 Buck Institute study, men and women aged 40–75 underwent either TPE alone, TPE + IVIG, or a placebo. Researchers calculated participants’ biological age using multiple validated aging clocks across genomic, proteomic, and metabolic markers.
Key findings:
- TPE + IVIG reversed biological age by an average of 2.6 years.
- TPE alone resulted in approximately 1.3 years of biological age reversal.
- Participants with higher baseline inflammation saw the most significant rejuvenation.
- Immune cell composition shifted toward a younger, more balanced state.
As Dr. Irina Conboy of the Buck Institute noted, “We now have quantifiable proof that systemic rejuvenation is achievable. It opens a path to therapies that not only slow aging but actively reverse it.”
Understanding IVIG: The Immune Rejuvenator
IVIG (Intravenous Immunoglobulin) is a purified solution of antibodies from healthy donors that helps balance immune function.
In the context of reversing biological age, IVIG serves as a biologic modulator—it reduces chronic inflammation and restores the immune system’s youthful responsiveness. When paired with TPE, IVIG amplifies rejuvenation by helping the body “remember” healthy immune communication patterns.
How Young Plasma Exchange® (YPE) Takes Reversal Further
At Austin Regenerative Therapy, our proprietary Young Plasma Exchange® (YPE) builds upon this emerging science by replacing aged plasma with biologically active, youthful plasma rich in regenerative components.
While traditional TPE simply removes aged plasma and replaces it with a neutral solution, YPE replenishes the system with plasma containing a full spectrum of biologic factors that support cellular regeneration:
- Immunoglobulins (like IVIG): for immune regulation and resilience
- Growth and repair factors: to optimize cell communication and tissue repair
- Anti-inflammatory cytokines: to reduce age-related inflammation
- Nutrient transport proteins and hormones: to enhance energy and metabolism
Where TPE resets, Young Plasma Exchange® rejuvenates—creating an internal environment that allows your body to function as though it were biologically younger.
This is the next generation of biological age reversal therapy—a comprehensive “refresh and replenish” system that supports whole-body regeneration.
Why Replacing Aged Plasma Matters
Aging isn’t just the passage of time; it’s a gradual breakdown in communication between cells. Over time, our plasma accumulates molecules that promote inflammation, oxidative stress, and metabolic decline.
By replacing aged plasma with biologically young plasma, Young Plasma Exchange® supports optimal signaling pathways that are essential for:
- Enhanced energy and recovery
- Sharper mental clarity
- Improved muscle and tissue repair
- Balanced immune function
- Healthier, more radiant skin
This isn’t about turning back the clock superficially—it’s about helping the body remember how to function at its most vital and regenerative state.
Ben Greenfield’s Experience with YPE
In his 2025 article, “10 Science-Backed Strategies for Revolutionizing Human Performance,” author and biohacker Ben Greenfield listed Young Plasma Exchange® among his Top 10 Biohacks of the Year.
He described YPE as “a powerful way to rejuvenate the internal environment and reset cellular communication.” After his experience at Austin Regenerative Therapy, Ben reported measurable improvements in energy, focus, and recovery—echoing what many of our clients describe: a renewed sense of vitality and cognitive sharpness following YPE therapy.
Integrating YPE Into a Whole-Person Longevity Strategy
While Young Plasma Exchange® delivers profound rejuvenation on a cellular level, it works best as part of a comprehensive longevity plan that aligns every aspect of health toward reversing biological age and extending your healthspan.
At Austin Regenerative Therapy, we personalize each plan to include:
- Hormone optimization based on lab results
- Nutrition and exercise programs customized to your biomarkers
- IV nutrient and peptide therapy to enhance energy and resilience
- Sleep and stress optimization protocols
- Continuous biomarker tracking to monitor progress over time
This integrated system—what we call whole-person longevity medicine, empowers the body to perform, recover, and regenerate with youthful efficiency.
The Future of Regenerative Medicine Is Already Here
The Buck Institute’s findings validate what we’ve observed clinically: when you refresh the body’s internal environment, reversing biological age becomes a measurable reality.
For too long, medicine has focused solely on disease management. Longevity medicine shifts the focus to extending quality of life—to helping you thrive in the decades before decline.
Young Plasma Exchange® represents the forefront of this new era—blending biologic precision, compassionate medical oversight, and a deep commitment to helping patients experience lasting vitality.
Key Takeaways
- A Buck Institute study (Aging Cell, 2025) showed TPE + IVIG reversed biological age by 2.6 years in humans.
- IVIG enhances immune recalibration, amplifying rejuvenation effects.
- Young Plasma Exchange® (YPE) goes further by replenishing aged plasma with biologically active youthful plasma.
- YPE therapy supports energy, cognition, immune health, and tissue repair.
- When integrated into a whole-person longevity strategy, YPE can play a pivotal role in reversing biological age and optimizing long-term vitality.
In Summary
We are entering a new age of regenerative medicine—one where reversing biological age is not theoretical but achievable.
At Austin Regenerative Therapy, we combine cutting-edge science with compassionate, personalized care to help you reclaim your vitality and live life at your fullest potential.
If you’re ready to explore how Young Plasma Exchange® therapy can support your longevity and performance, schedule your private concierge consultation today by calling 512-991-2560.
